Classified as a novel class of androgen receptor ligands, Selective androgen receptor modulators or SARMs are known to have the similar kind of effects as androgenic drugs such as anabolic androgenic steroids but they are much more selective in their action. This unique advantage allows SARMS to be used for more clinical indications than the very few limited uses for which steroids are presently approved for.
Here are the top 10 SARMS 1)Compreshensive information about SARMS can be found at https://www.isarms.com/selective-androgen-receptor-modulators :
A SARM developed to prevent and treat health conditions like muscle wasting, Ostarine (MK-2866) is prescribed by medical practitioners for health conditions such as sarcopenia 2)More info on sarcopenia with aging and muscle loss: http://www.webmd.com/healthy-aging/sarcopenia-with-aging, cachexia, and atrophy and also for Testosterone or Hormone replacement therapy.
Useful to maintain and increase lean body mass, MK-2866 stimulates growth of muscles in a manner similar to anabolic steroids but it does not produce the growth effect on prostate and other secondary sexual organs. This selective androgen receptor modulator is used by athletes and bodybuilders during recovery periods from injuries or surgeries to reduce muscle atrophy.
Known to be the most anabolic of any SARMS, Ostarine (MK-2866) is the best bulking drug for everyone who wants to gain lean muscle. One of the biggest advantages of Ostraine is that gains made with it are very keepable. It can also be made a part of cutting cycles for muscle mass maintenance while reducing calories. Use of this drug is associated with a drop in hormonal levels (IGF, T3, and Testosterone etc.) and metabolic rate that makes it easy for loss of muscle tissue.
Andarine (S-4) is one of the most sought-after drugs when it comes to treating severe health conditions such as osteoporosis, benign prostatic hypertrophy 3)Prostate Enlargement: Benign Prostatic Hyperplasia in depth: http://www.niddk.nih.gov/health-information/health-topics/urologic-disease/benign-prostatic-hyperplasia-bph/Pages/facts.aspx, and muscle wasting. One of the biggest advantages of S4 is that it does not have androgenic activity in non-skeletal muscle tissues. This SARMS is extremely beneficial to maintain and increase lean body mass and is rated extremely highly as an orally active partial agonist for androgen receptors.
In addition to these advantages, S4 has been scientifically proven to restore skeletal muscle and strength in castrated rats. In ovariectomized rats, S4 displays greater efficacy than Dihydrotestosterone (DHT) treatment when it comes to maintaining bone strength and mass to the levels of intact controls. It also proves beneficial to increase lean body mass, prevent bone loss, reduce body fat, and improve skeletal muscle strength.
S4 is one of the best cutting drugs for inducing concurrent reduction in body fat with muscle mass maintenance in a hypocaloric environment.
An orally administrated growth hormone secretagogue, Nutrobal (Mk-677) is similar to peptides such as Ipamorelin or GRP-6. This Growth Hormone Secretagogue chemically signals the pituitary gland to secret GH and is medically indicated for health conditions like obesity, osteoporosis, and muscle wasting. This SARM is also beneficial for treatment of elderly hip fracture patients.
This selective androgen receptor modulator is useful for increasing release of growth hormone releasing hormone, reducing release of somatostatin that turns off growth hormone release. It also proves beneficial to amplify growth hormone releasing hormone signaling in somatotrophs of the anterior pituitary gland and inhibition of somatostatin receptor signaling. Use of this drug is also found useful for inducing increase in bone density levels that proves beneficial for assistance during injury recovery during a cycle. In addition to this, Nutrabol also stimulates an increase in IGF-1 levels by 39-89 percent that helps in healing old injuries, tendons, bones, and ligaments, and increasing lean mass and fat loss.
GW501516 (also referred to as GW1516 or GSK-516) is a selective androgen receptor modulator known for reversing metabolic abnormalities in obese men with pre-diabetic metabolic syndrome. Also sold as Cardarine, this SARMS stimulates glucose uptake in skeletal muscle tissue and activates AMP-activated protein kinase 4)Resources on AMP Activatd Protein Kinase at Wikipedia: https://en.wikipedia.org/wiki/AMP-activated_protein_kinase.
It is commonly used by athletes and bodybuilders as results made with it are staggering and quick to stimulate endurance enhancements.
Stenabolic (SR-9009) is one of the very few substances that offer a wide range of benefits. Athletes and bodybuilders across the world use this SARMS to enhance endurance, increase fat loss, and enhance metabolism
SR-9009 also has the ability to reduce plasma insulin level, total cholesterol, plasma non-esterified fatty acids, plasma glucose, and plasma triglycerides. In addition to this, it also has the unique ability to reduce pro-inflammatory cytokine IL-6 5)The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages.: http://www.ncbi.nlm.nih.gov/pubmed/24736635 by a significant extent that proves extremely beneficial for reducing inflammation.
The newest compound in the family of SARMS, Testolone (RAD140) is best known for its ability to counter prostate enlargement caused by the use of Testosterone-based derivatives. It is for this reason that a big majority of athletes and bodybuilders use RAD-140 with highly androgenic steroids that can possibly cause enlargement of the prostate. Medically, it is prescribed for treating health conditions such as androgen deficiencies, sarcopenia, and muscle wasting diseases and this SARMS is used by athletes for dramatically improving recovery and endurance.
This investigational selective androgen receptor modulator was originally developed as potential male hormonal contraceptive. This SARMS binds to the androgen receptor more strongly than traditional drugs such as Andarine and it displays a good ratio of anabolic to androgenic effects and dose-dependent spermatogenesis suppression with spontaneous recovery after treatment cessation.
Originally developed for the treatment of osteoporosis, this investigational selective androgen receptor modulator has the ability to increase biomechanical strength of femoral cortical bone and bone mineral density in animal studies. However, it has now observable effect on the prostate gland and has relatively little effect on muscle mass.
Best suitable for use in women, S-40503 is a superior option for girls and women who want to stay protected against virilizing effects or suffer from osteoporosis.
Developed for treatment of muscle wasting and osteoporosis, LGD-2226 is an investigational selective androgen receptor modulator that demonstrates anabolic effects in both muscle and bone tissue. This orally active and selective agonist for androgen receptors is admired for its abilities to increase physical stamina and fitness and assist in training.
Classified as a non-steroidal androgen receptor ligand with mixed agonist and antagonist activity in androgen-responsive cell-based assays, JNJ-28330835 has demonstrated abilities to stimulate sexual behavior in female rats and enhance lean body mass in male rats. In animal studies, this SARM has shown ability to reduce prostate weight without having any inhibitory effect on muscle. JNJ-28330835 is regarded by many as a possible substance for treating muscle-wasting diseases and sexual function disorders in the future.
References [ + ]
|1.||↑||Compreshensive information about SARMS can be found at https://www.isarms.com/selective-androgen-receptor-modulators|
|2.||↑||More info on sarcopenia with aging and muscle loss: http://www.webmd.com/healthy-aging/sarcopenia-with-aging|
|3.||↑||Prostate Enlargement: Benign Prostatic Hyperplasia in depth: http://www.niddk.nih.gov/health-information/health-topics/urologic-disease/benign-prostatic-hyperplasia-bph/Pages/facts.aspx|
|4.||↑||Resources on AMP Activatd Protein Kinase at Wikipedia: https://en.wikipedia.org/wiki/AMP-activated_protein_kinase|
|5.||↑||The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages.: http://www.ncbi.nlm.nih.gov/pubmed/24736635|